Gwero lalikulu la helium ndi zitsime za gasi. Imapezedwa kudzera mu liquefaction and stripping operations.Chifukwa cha kuchepa kwa helium padziko lapansi, ntchito zambiri zimakhala ndi machitidwe obwezeretsa kuti abwezeretse helium.
Helium ili ndi ntchito zofunika kwambiri mu gawo lazamlengalenga, monga gasi yobweretsera ndi kuponderezana kwa zida za rocket ndi spacecraft, komanso ngati chosindikizira pamakina amadzimadzi apansi ndi ndege. Chifukwa cha kachulukidwe kakang'ono komanso kukhazikika kwake, helium nthawi zambiri imagwiritsidwa ntchito kudzaza ma baluni owonera nyengo ndi mabuloni osangalatsa kuti akweze. Helium ndi yotetezeka kuposa haidrojeni yoyaka moto chifukwa siwotcha kapena kuyambitsa kuphulika. Helium yamadzimadzi imatha kupereka malo otentha otsika kwambiri kuti agwiritsidwe ntchito muukadaulo wa superconducting ndi maginito a resonance imaging (MRI), kusunga kutentha kotsika kwambiri komwe kumafunikira maginito apamwamba.

Pazachipatala, helium imagwiritsidwa ntchito posungira malo okhala ndi cryogenic kwa ma superconductors pazida zamaginito zamaginito komanso chithandizo chothandizira monga kuthandizira kupuma. Helium imagwira ntchito ngati mpweya wodzitchinjiriza woteteza kuti asatengeke ndi okosijeni panthawi yowotcherera ndipo imagwiritsidwanso ntchito pozindikira gasi komanso ukadaulo wozindikira kutayikira kuti zitsimikizire kulimba kwa zida ndi makina. Mu kafukufuku wa sayansi ndi ma laboratories, helium imagwiritsidwa ntchito ngati chonyamulira cha gasi chromatography, ndikupereka malo oyesera okhazikika. Popanga semiconductor, helium imagwiritsidwa ntchito poziziritsa komanso kupanga malo oyera, kuwonetsetsa kukhazikika kwa njira yopangira komanso mtundu wazinthu.